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目的:观察苏黄止咳胶囊联合布地奈德治疗咳嗽变异性哮喘(CVA)的效果。方法:选取确诊的CVA 87例,随机分为观察组44例和对照组43例。两组均给予止咳、平喘、抗炎等常规治疗,对照组加用布地奈德气雾剂吸入治疗,观察组在对照组治疗基础上给予苏黄止咳胶囊口服。比较两组症状缓解时间,治疗前后1秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气峰值流量(PEF)等肺功能改善情况,以及治疗前后白介素6(IL-6)、肿瘤坏死因子α(TNF-α)、血清免疫球蛋白及T淋巴细胞水平。结果:观察组咳嗽缓解、消失时间及气喘、哮鸣音消失时间均显著或非常显著短于对照组(P<0.05,P<0.01)。治疗后,两组FEV1、FVC、PEF均较治疗前显著增加,观察组FEV1、FVC又显著高于对照组治疗后(P<0.05)。两组血清IL-6、TNF-α水平、IgE水平均较治疗前显著降低,IgG、IgM水平显著升高(P<0.05);治疗后,观察组血清IL-6、TNF-α水平显著低于对照组,IgG、IgM水平显著高于对照组(P<0.05)。观察组治疗后CD3~+、CD4~+、CD4~+/CD8~+均显著升高,CD8~+水平显著降低;对照组治疗后CD3~+水平显著增高(P<0.05);观察组CD3~+、CD4~+/CD8~+显著高于对照组治疗后(P<0.05)。两组不良反应发生率差异不显著(P>0.05)。结论:在常规治疗基础上,联合使用布地奈德与苏黄止咳胶囊治疗CVA,可增强患者免疫功能,降低炎症因子水平,更快缓解症状。
Objective: To observe the effect of Suhuangzhike Capsule combined with budesonide in treating cough variant asthma (CVA). Methods: 87 cases of diagnosed CVA were selected and randomly divided into observation group (44 cases) and control group (43 cases). The two groups were given conventional treatment of cough, asthma, anti-inflammatory and so on. The control group was treated with budesonide aerosol inhalation. The observation group was given Su Huang Zhi Ke Capsule on the basis of the control group. Before and after treatment, FEV1, FVC, PEF and other lung function improvement were compared between before and after treatment, interleukin 6 (IL-6), tumor Necrosis factor alpha (TNF-alpha), serum immunoglobulin and T lymphocyte levels. Results: The cough relief, disappearance time, asthma and wheeze disappearance time in the observation group were significantly or very significantly shorter than those in the control group (P <0.05, P <0.01). After treatment, the FEV1, FVC and PEF in both groups increased significantly compared with those before treatment, and the FEV1 and FVC in the observation group were significantly higher than those in the control group after treatment (P <0.05). The levels of serum IL-6, TNF-α and IgE in both groups were significantly lower than those before treatment, and the levels of IgG and IgM were significantly increased (P <0.05). After treatment, the levels of IL-6 and TNF- The levels of IgG and IgM in the control group were significantly higher than those in the control group (P <0.05). The levels of CD3 ~ +, CD4 ~ + and CD4 ~ + / CD8 ~ + in the observation group were significantly increased and the levels of CD8 ~ + were significantly decreased in the observation group. CD3 ~ + level was significantly increased in the control group (P < ~ +, CD4 ~ + / CD8 ~ + was significantly higher than that of the control group after treatment (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions: On the basis of routine treatment, the combined use of budesonide and Suhuangzhike capsule in the treatment of CVA can enhance immune function, reduce the level of inflammatory cytokines and relieve symptoms more quickly.