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采用放射免疫法检测54创急性白血病患儿的脑脊液β2微球蛋白（CSFβ2－MG），并对其中伴中枢神经系统白血病（CNSL）的10例患儿的CSFβ2－MG进行了动态观察。结果，27例CNSL患儿CSFβ2-MG为3．18±1．127，27例NCNSL患儿CSFβ2－MG为1．202±0．386，CNSL组明显高于NCNSL组，两者差异有显著意义。10例CNSL患儿治疗后，病情逐渐缓解，CSFβ2-MG逐渐下降，为1．263±0．278，与治疗前相比差异有显著意义，与NCNSL组相比差异无显著意义。3例CNSL患儿在出现临床症状及脑脊液检查异常前已出现CSFβ2－MG的改变。结果表明、GSFβ2-MG与CNSL的发生及发展有着密切的关系，CSFβ2-MG的检测可以作为早期诊断CNSL的客观指标之一，CSFβ2－MG的动态观察也可作为评价疗效的指标。
The cerebrospinal fluid β2-microglobulin (CSFβ2-MG) in 54 children with acute leukemia was detected by radioimmunoassay. The CSFβ2-MG in 10 children with central nervous system leukemia (CNSL) was dynamically observed. Results: CSFβ2-MG was 3.18±1.127 in 27 children with CNSL and 1.202±0.386 in 27 children with NCNSL. The CNSL group was significantly higher than NCNSL group, and the difference was significant between the two groups. . After treatment in 10 children with CNSL, the condition gradually relieved, and CSFβ2-MG gradually decreased, which was 1.263±0.278, which was significantly different from that before treatment. There was no significant difference compared with NCNSL group. Three patients with CNSL had CSFβ2-MG changes before clinical symptoms and cerebrospinal fluid abnormalities. The results show that there is a close relationship between GSFβ2-MG and the occurrence and development of CNSL. The detection of CSFβ2-MG can be one of the objective indicators for the early diagnosis of CNSL. The dynamic observation of CSFβ2-MG can also be used as an indicator to evaluate the efficacy.