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目的：测定急性肾小球肾炎患儿血和尿中一氧化氮和环鸟苷酸，以期了解一氧化氮在急性肾炎发病过程中的变化。 方法：分别采用分光光度和放射性免疫分析的方法测定了１７ 例急性肾小球肾炎急性期患儿血和尿中的ＮＯ－２ ／ ＮＯ－３ 和ｃＧＭＰ，并对６ 例患儿进行了急性期和恢复期的动态观察。 结果：１７ 例急性期患儿血中ＮＯ 明显升高（６９－２ ±１５－７ μｍ ｏｌ／Ｌ ｖｓ ３１－３ ±４－６ μｍ ｏｌ／Ｌ，Ｐ＜ ０－０５） ，尿中ｃＧＭＰ 降低（３６６－１ ±３９－０ｐ ｍｏｌ／ ｍ ｇ ｖｓ６３７－６ ±７８－６ ｐｍ ｏｌ／ ｍ ｇ ，Ｐ＜ ０－０５） ，但尿中ＮＯ－２ ／ ＮＯ－３ 和血ｃＧＭＰ 与正常对照组差异不显著。动态观察的６ 例患儿急性期尿ＮＯ 和ｃＧＭＰ 明显低于恢复期（５９０－８ ±１４１－４ ｎ ｍｏｌ／ ｍ ｇ ｖｓ １６０５－６ ±１４９－２ ｎ ｍ ｏｌ／ ｍ ｇ ，Ｐ＜ ０－０５） ；（２８３－４ ±６１－７ ｐｍ ｏｌ／ ｍ ｇ ｖｓ １０８３－３ ±３３６－９ ｐ ｍｏｌ／ ｍｇ ，Ｐ＜ ０－０５） 。同时急性期血中ＮＯ 明显高于恢复期（１０５－９ ±２７－３ μｍｏｌ／ Ｌｖｓ ４６－５ ±１０－１ μｍ ｏｌ／Ｌ，Ｐ＜ ０－０５） 。 结论：急性肾炎患儿在?
Objective: To determine the levels of nitric oxide and cGMP in blood and urine of children with acute glomerulonephritis in order to understand the changes of nitric oxide in the pathogenesis of acute nephritis. Methods: The levels of NO-2 / NO-3 and cGMP in blood and urine of 17 children with acute glomerulonephritis were determined by spectrophotometry and radioimmunoassay. The acute phase And the dynamic observation of recovery period. Results: Serum NO was significantly increased in 17 children with acute phase (69-2 ± 15-7 μmol / L vs 31-3 ± 4-6 μmol / L, P <0-05), while urinary cGMP was decreased (366-1 ± 39-0p mol / m g vs 637-6 ± 78-6 pm ol / m g, P <0-05). However, there were no significant differences in NO-2 / NO-3 and blood cGMP levels between the two groups Not obvious. The dynamic changes of NO and cGMP in acute phase of 6 cases were significantly lower than those in convalescent stage (590-8 ± 141-4 n mol / m g vs 1605-6 ± 149-2 nmol / m g, P < 05); (283-4 ± 61-7 pm ol / m g vs 1083-3 ± 336-9 p mol / mg, P <0-05). At the same time, NO in acute phase was significantly higher than that in convalescent phase (105-9 ± 27-3 μmol / L vs 46-5 ± 10-1 μmol / L, P <0-05). Conclusion: Acute nephritis in children?