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目的:研究楤木皂苷对四氯化碳致大鼠肝纤维化的防治作用,并探讨其作用机制。方法:采用40%四氯化碳皮下注射诱导大鼠肝纤维化模型,楤木皂苷给药8周,检测大鼠肝脾指数、肝功能及血清透明质酸(HA)、三型胶原(COI-Ⅲ)、四型胶原(COI-Ⅳ)的变化。结果:楤木皂苷(30 mg/kg、60 mg/kg)可改善肝功能,降低肝脾指数及血清HA、COI-Ⅲ、COI-Ⅳ的含量。结论:楤木皂苷可改善肝功能,有抗纤维化作用。
Objective: To study the prevention and treatment of alzarin on liver fibrosis induced by carbon tetrachloride (CCl4) in rats and its mechanism of action. Methods: The model of hepatic fibrosis was induced by subcutaneous injection of 40% carbon tetrachloride for 8 weeks. The liver and spleen index, liver function, serum hyaluronic acid (HA), collagen III (COI) -Ⅲ), type IV collagen (COI-Ⅳ) changes. Results: Almus saponins (30 mg / kg, 60 mg / kg) could improve liver function, reduce the content of liver and spleen index and serum HA, COI-Ⅲ and COI-Ⅳ. Conclusion: Almus saponins can improve liver function, anti-fibrosis.