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自使用百日咳全细胞菌苗以来,美国报告的百日咳发病率和死亡率急剧下降(从1934年的每年25万余例,死亡7000例,下降至1975年以来的每年1～3000例,死亡5～15例)。但百日咳全细胞菌苗(与白喉和破伤风类毒素混合即DPT)可引起许多不良反应,如常见的轻度局部反应、发热和罕见而严重的永久性脑损害。因此,公共卫生决策者、医务人员、公众以及菌苗制造商都希望发展一种免疫效果与DPT相同,但副作用很小的百日咳菌苗。百日咳全细胞菌苗引起不良反应的成分
Since the use of B. pertussis whole-cell vaccine, the incidence and mortality of pertussis reported by the United States have dropped sharply (from 250,000 cases per year in the year of 1934 to 7,000 cases, down from 7000 cases per year to 1 to 3000 cases per year since 1975, 15 cases). However, B. pertussis whole-cell vaccine (mixed with diphtheria and tetanus toxoid, or DPT) can cause many adverse reactions, such as common mild local reactions, fever and rare and severe permanent brain damage. As a result, public health policymakers, health workers, the general public, and vaccine manufacturers are all hoping to develop a vaccine against pertussis that has the same immunosuppressive effects as DPT with little side effects. Pertussis whole cell vaccine caused adverse reactions of ingredients