【摘 要】
：
Wnt/β-catenin信号是一条进化上高度保守且极度复杂的发育信号通路,可调控胚胎发育、损伤修复以及多种人类疾病的发生、发展.大量证据表明,Wnt/β-catenin信号在肾脏早期发育中起关键作用,而在成年肾脏中则相对沉默.在多种肾脏病动物模型和人类肾脏疾病中它又被重新激活.急性肾损伤后Wnt/β-catenin的激活有助于受损肾小管的修复和再生.然而,该信号的持续激活与慢性肾脏疾病和肾纤维化的发生、发展密切相关.在本文中,我们对Wnt/β-catenin信号通路的组成及其转导机制,以及它在肾脏损伤后
【机 构】
：
南方医科大学南方医院肾内科,器官衰竭防治国家重点实验室,国家肾脏病临床医学研究中心,广州510515
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Wnt/β-catenin信号是一条进化上高度保守且极度复杂的发育信号通路,可调控胚胎发育、损伤修复以及多种人类疾病的发生、发展.大量证据表明,Wnt/β-catenin信号在肾脏早期发育中起关键作用,而在成年肾脏中则相对沉默.在多种肾脏病动物模型和人类肾脏疾病中它又被重新激活.急性肾损伤后Wnt/β-catenin的激活有助于受损肾小管的修复和再生.然而,该信号的持续激活与慢性肾脏疾病和肾纤维化的发生、发展密切相关.在本文中,我们对Wnt/β-catenin信号通路的组成及其转导机制,以及它在肾脏损伤后修复和纤维化过程中的作用进行较为系统的综述.深入阐明此信号通路的机制可能为将来防治肾脏病提供新的靶点和策略.
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