目的探讨米非酮在中期妊娠引产中的疗效。方法将2010年1月至2011年6月景德镇市妇幼保健院的孕14～28周引产的183例孕妇随机分为两组,观察组羊膜腔内注利凡诺尔,同时口服米非司酮;对照组单纯羊膜腔内注射利凡诺尔。结果观察组平均引产时间为(32±8)h,总产程(6.6±3.2)h;对照组平均引产时间为(44±8)h,总产程(12.0±2.8)h。观察组引产成功率高于对照组,引产时间及产程明显短于对照组,两组出血量比较差异无统计学意义。结论米非司酮联合利凡诺尔在中期妊娠引产中的使用是安全而有效的方法。 Objective To investigate the efficacy of mifeprone in induction of labor during second trimester pregnancy. Methods From January 2010 to June 2011, 183 pregnant women who induced labor in 14- 28 weeks’ gestation in Jingdezhen MCH hospital were randomly divided into two groups. The observation group received Rifalnone in the amniotic cavity and oral mifepristone. Control group simply amniotic injection of rivanol. Results The average duration of labor in the observation group was (32 ± 8) h and the duration of labor was (6.6 ± 3.2) h. The mean induction time in the control group was (44 ± 8) h and the duration of labor was (12.0 ± 2.8) h. The success rate of induction of labor in the observation group was higher than that in the control group, and the time of labor and labor were significantly shorter than the control group. There was no significant difference in the amount of bleeding between the two groups. Conclusion The combination of mifepristone and rivanol in induction of labor during the second trimester of pregnancy is a safe and effective method.