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目的:评价康唑类二联用药治疗顽固性霉菌性阴道炎的临床疗效。方法:选取2012年4月-2014年8月我所收治的顽固性霉菌性阴道炎患者100例,随机分为两组,其中观察组50例,选用氟康唑联合咪康唑进行治疗,对照组50例,仅选用咪康唑进行治疗,观察并比较两组患者临床疗效与不良反应。结果:观察组临床疗效(92.0%)优于对照组(68.0%),比较差异有统计学意义(P<0.05);两组患者均未产生明显不良反应,比较差异无统计学意义(P>0.05)。结论:康唑类二联用药治疗顽固性霉菌性阴道炎的临床疗效好,能有效降低患者复发率,且无明显不良反应,值得在临床上予以推广。
Objective: To evaluate the clinical efficacy of two-drug conazole in the treatment of refractory fungal vaginitis. Methods: From April 2012 to August 2014, 100 patients with refractory mycotic vaginitis admitted from April 2012 to August 2014 were randomly divided into two groups, of which 50 patients in the observation group were treated with fluconazole combined with miconazole, Group of 50 cases, only the choice of miconazole treatment, observation and comparison of two groups of patients with clinical efficacy and adverse reactions. Results: The clinical efficacy (92.0%) in the observation group was superior to that in the control group (68.0%), with significant difference (P <0.05). No significant adverse reactions were found in both groups, with no significant difference (P> 0.05). Conclusion: The combination therapy of cannac both in refractory fungal vaginitis has a good clinical curative effect, which can effectively reduce the recurrence rate of patients and has no obvious adverse reactions. It is worth to be popularized clinically.