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作者发现大多数氟喹诺酮有明显的剂量依赖,较高的药物浓度导致生长指数的降低。AT-4140,PD-127391,PD-124816,PD-117596,OPC-17100,OPC-17066和WIN-57273为活性最强的化合物,当浓度为0.31μg/ml时,其生长指数明显降低(p<0.001)。这与用Buddemeyer系统所进行的3次初步实验结果一致。在早期的氟喹诺酮中,氟嗪酸活性最强,浓度为0.31μg/ml时有显著的抑制作用。Temafloxacin浓度在0.3-1.25μg/ml时有活性。Fleroxacin剂量应答稍有异常,但总的来说活性略强于环丙氟哌酸和
The authors found that most fluoroquinolones have a significant dose-dependent, with higher drug concentrations resulting in a decrease in the growth index. AT-4140, PD-127391, PD-124816, PD-117596, OPC-17100, OPC-17066 and WIN-57273 were the most active compounds with a significantly decreased growth index at 0.31 μg / <0.001). This is consistent with the results of the three preliminary experiments conducted using the Buddemeyer system. Of the early fluoroquinolones, trifluoperazine had the strongest inhibitory activity at a concentration of 0.31 μg / ml. Temafloxacin is active at concentrations of 0.3-1.25 μg / ml. The Fleroxacin dose response was slightly abnormal, but in general the activity was slightly stronger than that of ciprofloxacin and