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铂类是非小细胞肺癌化疗的基本药物,它的耐药机制复杂,其中DNA损伤修复能力改变是铂类耐药的重要分子基础。全文综述DNA损伤修复机制——碱基切除修复、核苷酸切除修复、酶修复及DNA双链断裂修复等研究进展。
Platinum is the basic drug for non-small cell lung cancer chemotherapy. Its mechanism of drug resistance is complex. The change of DNA damage repair ability is an important molecular basis of platinum resistance. The paper reviews the research progress of DNA damage repair mechanism - base excision repair, nucleotide excision repair, enzyme repair and DNA double strand break repair.