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目的探讨 CD44v6 mRNA 及其蛋白表达与食管癌病理生物学行为的关系,为观测食管癌侵袭转移潜能和评估胃癌患者预后寻求一个新的客观生物学指标.方法应用 CSA 法原位杂交和免疫组化技术,检测65例食管癌组织中 CD44v6 mRNA 及其蛋白表达。并结合肿瘤的病理生物学行为和临床随访资料分析.结果在食管癌中 CD44v6 mRNA 和其蛋白表达阳性率分别为61.5%(40/65)和58.55(38/65),其表达均与食管癌浸润,淋巴结转移和预后密切相关(P<0.05).结论检测 CD44v6表达可作为预测食管癌转移潜能和评估患者预后的一个新的生物学指标.
Objective To investigate the relationship between the expression of CD44v6 mRNA and its protein and the pathological biological behavior of esophageal cancer, and to find a new objective biological index for observing the invasion and metastasis of esophageal cancer and evaluating the prognosis of gastric cancer. Methods In situ hybridization and immunohistochemistry using CSA method Techniques for the detection of CD44v6 mRNA and protein expression in 65 cases of esophageal cancer. Combined with the pathological biological behavior of the tumor and clinical follow-up data analysis, the positive rate of CD44v6 mRNA and its protein expression in esophageal cancer was 61.5% (40/65) and 58.55 (38/65), respectively, and its expression was associated with esophageal cancer. Infiltration, lymph node metastasis and prognosis were closely related (P<0.05). Conclusion The detection of CD44v6 expression can be used as a new biological indicator to predict the metastatic potential of esophageal cancer and evaluate the prognosis of patients.