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目的:测定口服二巯基丙磺酸钠( D M P S)的体内分布并观察其驱汞效果.方法:用 H P L C分离,荧光检测器测定了 D M P S在血和尿中含量,用配有冷原子发生器的原子吸收分光光度计测定尿汞含量.结果:口服 300M G D M P S后4 H 血液中达到高峰, D M P S主要以和蛋白质结合的形式存在于血浆中.口服 D M P S后 9 H,大部分 D M P S以结合成二硫化合物的形式从尿中排出.对龋齿作充填者,口腔科技师,含汞皮肤洗剂生产者口服 D P M P300 M G 进行驱汞试验,3 组不同的接汞人群无论投药前还是投药后,尿汞排泄量均明显高于相应的对照组.龋齿作充填者,口腔科技师,含汞皮肤洗剂生产者用药后尿汞排泄量比投药前分别增加了 24、87 和 44 倍.结论:口服 D M P S是一种安全、简便、有效的驱汞方法.“,”Objective:This papar was to determine the distribution of sodium 2,3 dimercapto l propanesulfonate (DMPS) in the body and observe the effects of it on removing mercury. Methods:We determined the plasmic and urinary contents of DMPS by HPLC separation and fluorescence detection. The urinary mercury levels were analysed by cold vapor generation atomic absorption spectrophotometer. A 300 mg DMPS challenge test for mercury was given to persons with dental amalgams, dental technicians and skin lotion makers. Results:Total DMPS was reached the peak mean concentration in 4 hours after oral administration of 300 mg DMPS. DMPS was mainly bound to protein in plasma. By 9 hours after oral administration, most of the DMPS was excreted from urine in DMPS disulfide forms. The mean urinary mercury levels were significantly higher in the three groups exposed to mercury than those in corresponding control groups both before and after DMPS administration. The increase in urinary mercury from DMPS challenge test was 24,87,and 44 fold respectively in persons with dental amalgams, dental technicians and skin lotion makers groups. Conclusion:The oral administration of DMPS was a safe, simple and effective method for the removal of mercury from the body. Conclusion:The oral administration of DMPS was a safe, simple and effective method for the removal of mercury from the body. The oral administration of DMPS was a safe, simple and effective method for the removal of mercury from the body.