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癫痫是一种慢性脑部疾病。以脑部神经元过度同步化放电所致的突然、反复和短暂的中枢神经系统功能失常为特征。细胞凋亡(apoptosis)是由基因控制的由细胞内部程序激活而发生的自杀性死亡,它在细胞分化、促进体内正常细胞的更新和调节机体发育等方面都起到重要作用。细胞凋亡是癫痫发作后神经元丢失的重要形式。目前认为,癫痫发作后细胞凋亡分子水平的多重调控主要集中在三个方面:(1)细胞凋亡的相关基因及其调控方面;(2)caspase(cysteine proteinases with specificity for aspartic acidresidues,半胱天冬氨酸酶)在细胞凋亡中的作用;(3)线粒体途径在细胞凋亡中的作用。
Epilepsy is a chronic brain disease. It is characterized by sudden, repetitive and transient central nervous system dysfunction caused by overynchronized discharge of brain neurons. Apoptosis is a gene-controlled suicide death triggered by the activation of intracellular processes. It plays an important role in cell differentiation, promotion of normal cell renewal and regulation of body development. Apoptosis is an important form of neuronal loss after seizures. At present, it is thought that the multiple regulation of apoptosis molecular level after epileptic seizure mainly focuses on three aspects: (1) related genes of apoptosis and their regulation; (2) cysteine proteinases with specificity for aspartic acidresidues Aspartase) in apoptosis; (3) the role of the mitochondrial pathway in apoptosis.