目的为掌握成都市手足口病流行规律,有针对性提出防治措施建议。方法通过国家疫情网收集2011年手足口病疫情信息,通过qRT-PCR方法实施病原体检测。结果成都市2011年手足口病报告发病18 284例,其中重症283例,死亡3例,年报告发病率125.22/10万,病死率低于全国平均水平,无暴发疫情发生。四季均发病,呈双峰流行,5岁以下儿童是主要发病人群,病原体优势毒株由EV71向CoxA16转变的趋势。结论 2011年成都市手足口病总体发病水平较高,但病死率低,无暴发疫情,早期预警和治疗可有效预防暴发和降低病死率。 Objective To grasp the epidemic law of hand, foot and mouth disease in Chengdu and put forward the prevention and cure suggestions. Methods The epidemic situation of HFMD in 2011 was collected through the national epidemic network and the pathogen detection was performed by qRT-PCR. Results In 2011, 18 284 cases of hand-foot-mouth disease were reported in Chengdu, of which 283 cases were severe and 3 died. The annual incidence rate was 125.22 / 100 000. The case fatality rate was lower than the national average level, and no outbreak occurred. All four seasons were onset, showing a bimodal epidemic, children under 5 years of age is the main incidence of the crowd, the pathogen dominant strains from EV71 to CoxA16 trend. Conclusion In 2011, the overall incidence of HFMD in Chengdu was high, but its mortality was low and no outbreak was detected. Early warning and treatment could effectively prevent outbreaks and reduce mortality.