在胰岛素治疗中降低剂量是很重要的,前曾报道胰岛素栓剂如以粉末胰岛素制成溶出很慢,而将酸性胰岛素溶液加入三甘油酯基质可使其释放加快,改善了生物利用度。本研究应用甘露醇或水杨酸钠使胰岛素成固体分散,在1小时内能达完全释放,比前报道的处方1小时只能释放50%快得多,仅0.5单位/公斤胰岛素就能生效,显著降低血糖水平。 It is important to reduce the dose in insulin therapy. Insulin suppositories have been reported to dissolve very slowly, as with powdered insulin. Adding an acidic insulin solution to the triglyceride matrix increases release and improves bioavailability. In this study, mannitol or sodium salicylate was used to disperse insulin into a solid and achieve complete release within 1 hour, which was only 50% faster than the previously reported formula, and only 0.5 unit / kg of insulin would be effective , Significantly lower blood sugar levels.