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目的:观察血府逐瘀汤对荷瘤小鼠免疫功能的影响,探讨血府逐瘀汤的抗肿瘤效果及其抗肿瘤的免疫学机制。方法:小鼠造模后给予不同药物治疗,10d后观察药物对瘤重和脾细胞功能的影响。结果:血府逐瘀汤能够显著抑制瘤重,活化T淋巴细胞增殖能力,提高荷瘤小鼠脾脏L3 T4+ 细胞数量,升高L3 T4+ /Lyt - 2 + 细胞比值,促进IL - 2的分泌,但对Lyt- 2 + 细胞数量影响不大。结论:血府逐瘀汤能够完全逆转肿瘤抗原和环磷酰胺引起的免疫抑制,其抑瘤作用与增强机体细胞免疫功能有关。
Objective: To observe the effect of Xuefu Zhuyu Decoction on immune function of mice with tumor-bearing, and to explore the anti-tumor effect of Xuefu Zhuyu Decoction and its anti-tumor immunological mechanism. Methods: The mice were given different drugs after modeling, and the effect of drugs on tumor weight and spleen cell function was observed after 10 days. Results: Xuefu Zhuyu Decoction could significantly inhibit the tumor weight, activate T lymphocyte proliferation, increase the number of L3 T4 + cells in spleen of tumor - bearing mice, increase the ratio of L3 T4 + / Lyt - 2 + cells and promote the secretion of IL - 2. But had little effect on the number of Lyt- 2 + cells. Conclusion: Xuefu Zhuyu Decoction can completely reverse the immunosuppression caused by tumor antigen and cyclophosphamide, and its anti-tumor effect is related to the enhancement of cellular immune function.