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目的探讨母血中胎儿有核红细胞数量与巨细胞病毒宫内感染之间的关系。方法收集54例巨细胞病毒宫内感染孕妇和68例非感染孕妇的外周血样本,富集胎儿有核红细胞后计数。每例样本取2个胎儿有核红细胞并用PEP-PCR技术证实其胎源性。结果宫内感染组的胎儿有核红细胞数量与100个有核细胞数的比值显著高于非感染组(P<0.05)。结论巨细胞病毒宫内感染孕妇外周血中的胎儿有核红细胞数量比正常妊娠者增高,对进一步阐明该病的病生机制具有一定的意义。
Objective To investigate the relationship between the number of fetal erythrocytes in maternal blood and intrauterine cytomegalovirus infection. Methods Peripheral blood samples of 54 pregnant women with cytomegalovirus intrauterine infection and 68 non-infected pregnant women were collected and enumerated. Two fetal nucleated erythrocytes were taken from each sample and their fetal origin was confirmed by PEP-PCR. Results The ratio of fetal nucleated erythrocytes to 100 nucleated cells in intrauterine infection group was significantly higher than that in non-infected group (P <0.05). Conclusion The number of fetal erythrocytes in peripheral blood of pregnant women with intrauterine cytomegalovirus infection is higher than that of normal pregnancy, which is of significance to further clarify the pathogenesis of the disease.