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作用模式双嘧达莫(Dipyridamole,潘生丁),抑制细胞再摄取腺苷(强效小冠脉扩张剂),而使内源性腺苷的细胞外水平增加;抑制磷酸二酯酶,促进前列环素合成。故能扩张小冠脉阻力血管。近年来提出,腺苷作用于血管平滑肌细胞的腺苷A_2受体,激活鸟苷酸环化酶,而促进环磷鸟苷(Cyclic guanosine monopho-spbate,cGMP)的合成,最终导致血管平滑肌松弛。氨茶碱可拮抗腺苷的作用。静脉或冠脉注射氨茶碱后,可见双嘧达莫的作用被抵消。因而,纠治双嘧达莫的副作用时,首选氨茶
Mode of action dipyridamole (Dipyridamole, dipyridamole, inhibition of cell reabsorption of adenosine (potent small coronary dilating agent), leaving the endogenous adenosine extracellular levels; inhibit phosphodiesterase, promote prostacyclin synthesis. It can dilate the small coronary resistance blood vessels. In recent years, adenosine has been suggested to act on the adenosine A 2 receptor of vascular smooth muscle cells and activate guanylate cyclase to promote the synthesis of cyclic guanosine monopho-spbate (cGMP), which eventually leads to relaxation of vascular smooth muscle. Aminophylline can antagonize the role of adenosine. After intravenous or coronary injection of aminophylline, the effect of dipyridamole was offset. Therefore, the correction of dipyridamole side effects, the preferred ammonia tea