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本文对５０对不明原因自然流产次数不同的夫妇和３０对已生育正常胎儿无流产史的夫妇染色体着丝粒点（Ｃｄ）进行了研究，其中流产夫妇按流产次数１、２、３及以上分为流产Ⅰ、Ⅱ、Ⅲ组。结果：Ｃｄ消失频率：流产组Ⅱ（０．３７±０．２０／细胞）和流产组Ⅲ（０．４２±０．２２／细胞）分别与正常对照组（０．７１±０．１２／细胞）比较差异有极显著意义（Ｐ＜０．０１）。Ｃｄ变异频率：流产组Ⅰ（０．６９±０．２８／细胞）、流产组Ⅱ（０．６７±０．２８／细胞）和流产组Ⅲ（０．６７±０．２１／细胞）分别与正常对照组比较差异有极显著意义（Ｐ＜０．０１）。Ｃｄ－ＮＯＲ融合频率：流产组Ⅱ（０．４０±０．２０／细胞）和流产组Ⅲ（０．４１±０．１９／细胞）与正常对照组（０．１９±０．１８／细胞）比较差异有极显著意义（Ｐ＜０．０１）。Ｃｄ融合频率：流产组Ⅱ（０．３５±０．１７／细胞）和流产组Ⅲ（０．３７±０．１３／细胞）分别与对照组（０．２６±０．１８／细胞）比较差异有显著意义（Ｐ＜０．０５）。总体趋势表现为流产组ⅡＣｄ变化的各项指标有较显著的提高，提示：不明原因流产２次以上的夫妇Ｃｄ的变化可能是导致流产的重要原因之一。
In this paper, 50 pairs of couples with different causes of spontaneous abortion and 30 pairs of couples with no history of miscarriage of normal fetus were studied for centromere (Cd). The abortion rate was calculated as 1, 2, 3 and above Abortion Ⅰ, Ⅱ, Ⅲ group. Results: The frequency of Cd disappearance was significantly higher in abortion group Ⅱ (0.37 ± 0.20 / cell) and abortion group Ⅲ (0.42 ± 0.22 / cell) than in normal control group (0.71 ± 0.12 / cell ) Was significantly different (P <0.01). The frequencies of Cd mutation in abortion group Ⅰ (0.69 ± 0.28 / cell), abortion group Ⅱ (0.67 ± 0.28 / cell) and abortion group Ⅲ (0.67 ± 0.21 / cell) The difference between the normal control group was significant (P <0.01). The frequency of Cd-NOR fusion was significantly higher in abortion group Ⅱ (0.40 ± 0.20 / cell) and abortion group Ⅲ (0.41 ± 0.19 / cell) than in normal control group (0.19 ± 0.18 / cell) The difference was significant (P <0.01). The frequency of Cd fusion was compared with that of the control group (0.26 ± 0.18 / cell) in miscarriage group Ⅱ (0.35 ± 0.17 / cell) and abortion group Ⅲ (0.37 ± 0.13 / cell) Significant (P <0.05). The overall trend showed that the change of Ⅱ Cd in abortion group had a significant increase, suggesting that the change of Cd in couples with unexplained abortion more than twice could be one of the important causes of abortion.