葡萄球菌肠毒素(staphylococcal enterotoxin,SE)是一种外源性超抗原,仅需微量即能高效刺激T淋巴细胞增殖,促使其产生细胞毒作用,并释放大量的细胞因子,引发机体自身免疫应答。大量研究表明,SE是一种很有前途的新型肿瘤免疫治疗制剂,目前国内已将SEC2应用于肿瘤患者的治疗及对肿瘤患者在进行放化疗时防止白细胞降低。该文综述了SEC2在生物学活性、结构特性、抑制肿瘤细胞生长作用等方面的研究进展。 Staphylococcal enterotoxin (SE) is an exogenous superantigen, which can efficiently stimulate the proliferation of T lymphocytes, induce cytotoxicity and release a large amount of cytokines, triggering the body’s autoimmune response . A large number of studies have shown that SE is a promising new type of tumor immunotherapy preparations, currently SEC2 has been applied to the treatment of cancer patients and cancer patients in the prevention of leukopenia during chemoradiation. This review summarizes the research progress of SEC2 in biological activity, structural characteristics, inhibition of tumor cell growth and so on.