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为研究乙型肝炎患者红细胞ＣＲ１活性与ＣＲ１密度相关基因多态型别的关系，采用ＰＣＲ加ＨｉｎｄⅢ酶切技术测定红细胞ＣＲ１密度相关基因多态型别（ＨＨ、ＨＬ、ＬＬ型），采用红细胞ＣＲ１（ＥＣＲ１）免疫粘附活性（ＲＣＩＡ）和粘附ＩＣ量免疫酶联（ＥＬＩＳＡ）法测定红细胞ＣＲ１活性。乙型肝炎患者ＨＨ型比率是７３９％（３４／４６），正常人ＨＨ型比率是８０％（６４／８０），ＨＨ型乙型肝炎患者ＥＣＲ１ＲＣＩＡ（３７８±０２９ｎｇＡＨＧ／１０７ＲＢＣ）明显高于ＨＬ型乙型肝炎患者（１８８±０２６ｎｇＡＨＧ／１０７ＲＢＣ）和ＨＨ型正常人（２６０±０３０ｎｇＡＨＧ／１０７ＲＢＣ）。提示乙型肝炎患者红细胞免疫功能低下是获得性的。
To investigate the relationship between erythrocyte CR1 activity and CR1 density-related gene polymorphism in patients with hepatitis B, PCR-HindⅢ restriction enzyme digestion was used to determine the polymorphisms of CR1-related genes (HH, HL and LL) in erythrocytes. (ECR1) Immunoadhesive Activity (RCIA) and Adhesion ICs were measured by enzyme-linked immunosorbent assay (ELISA). The HH rate was 739% (34/46) in patients with hepatitis B, 80% (64/80) in normal subjects, and 3 RRRs (137.83 ± 0.29 ngAHG / 107RBC) in patients with HH hepatitis B, (1.88 ± 0.26ngAHG / 107RBC) and normal HH type (260 ± 0.30ngAHG / 107RBC) in patients with HL type. Prompt Hepatitis B patients with erythrocyte immune dysfunction is acquired.