细胞外刺激能够诱导细胞内即早基因快速一过性表达，其表达产物包括转录因子和细胞因子（ｃｙｔｏｋｉｎｅ）。即早基因ｃ－ｆｏｓ、ｃ－ｊｕｎ和ｆｏｓ、ｊｕｎ相关基因的表达产物是转录因子ＡＰ－１的组成成分。一般认为即早基因参与偶联神经元的兴奋性和细胞的应答反应。本文综述了惊厥后神经元兴奋一转录偶联的有关分子机制。 Extracellular stimulation can induce rapid transient expression of immediate early genes in cells, including expression of transcription factors and cytokines. That early genes c-fos, c-jun and fos, jun related gene expression product is a transcription factor AP-1 components. It is generally accepted that immediate early genes are involved in the excitability of coupled neurons and cellular responses. This article reviews the molecular mechanisms of excitatory-transcriptional coupling in post-convulsive neurons.