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目的观察动脉粥样硬化性脑梗死(ACI)患者血清氧化低密度脂蛋白(ox-LDL)、金属基质蛋白-9(MMP-9)、C反应蛋白(CRP)水平与颈动脉斑块之间的相关性。方法选取我院110例ACI患者作为观察组,选取同期行体检的健康人群100例作为对照组,用酶联免疫吸附试验(ELISA)法检测2组血清ox-LDL、CRP和MMP-9水平,同时对ACI患者行颈动脉超声检测。结果观察组,血清ox-LDL、CRP和MMP-9水平明显高于对照组[(261.54±24.51)vs(146.51±19.59)μg·mL~(-1);(4.54±1.21)vs(0.87±0.15)μg·mL~(-1);(139.76±41.22)vs(65.76±23.48)ng·mL~(-1),均P<0.01);ACI患者中,有斑块组患者血清ox-LDL、CRP和MMP-9水平明显高于无斑块组[(205.27±20.11)vs(162.50±19.71)μg·mL~(-1);(4.32±1.03)vs(1.21±0.10)μg·mL~(-1);(90.71±24.03)vs(71.71±23.21)ng·mL~(-1),均P<0.01),且三者呈正相关性。结论血清ox-LDL、CRP和MMP-9水平升高是ACI患者颈动脉斑块形成的独立危险因素,其可作为诊断ACI和颈动脉斑块形成的重要参考指标。
Objective To observe the changes of serum levels of ox-LDL, MMP-9 and C-reactive protein (CRP) in patients with atherosclerotic cerebral infarction (ACI) and carotid plaques Relevance. Methods A total of 110 patients with ACI in our hospital were selected as the observation group and 100 healthy subjects in the same period were selected as the control group. The levels of serum ox-LDL, CRP and MMP-9 in the two groups were detected by enzyme-linked immunosorbent assay (ELISA) At the same time, ACI patients underwent carotid ultrasound. Results The levels of serum ox-LDL, CRP and MMP-9 in the observation group were significantly higher than those in the control group [(261.54 ± 24.51) vs (146.51 ± 19.59) μg · mL -1; (4.54 ± 1.21 vs vs 0.87 ± 0.15) μg · mL -1; (139.76 ± 41.22) vs (65.76 ± 23.48) ng · mL -1, all P <0.01). In the patients with ACI, , CRP and MMP-9 levels were significantly higher than those in the non-plaque group (205.27 ± 20.11 vs 162.5 ± 19.71 μg · mL -1 vs 4.21 ± 1.03 vs 1.21 ± 0.10 μg · mL -1, (-1); (90.71 ± 24.03) vs (71.71 ± 23.21) ng · mL -1, all P <0.01), and there was a positive correlation between them. Conclusions Elevated levels of serum ox-LDL, CRP and MMP-9 are independent risk factors for carotid plaque formation in ACI patients, which may be used as an important reference for diagnosis of ACI and carotid plaque formation.