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目的探讨脱氢表雄酮对老年男性体脂分布与血脂的影响。方法对照分析６４例老年肥胖男性者［体重指数（ＢＭＩ）≥２５］口服不同剂量脱氢表雄酮硫酸酯后体脂与血脂的变化。结果口服脱氢表雄酮硫酸酯２５ｍｇ，每日１次，３月后较服药前ＢＭＩ下降（３６９±０５２）％、股骨皮下脂肪厚度减少（６４８±２２１）％、肾周脂肪减少（２４２±１９１）％。口服脱氢表雄酮硫酸酯５０ｍｇ，每日１次，３月后较服药前ＢＭＩ下降（２３６±０７２）％、股骨皮下脂肪厚度减少（１６７±０８９）％、肾周脂肪减少（２８７±１４７）％。２组与对照组有明显差别（Ｐ＜００５）。血脂未发现明显变化。结论老年人口服脱氢表雄酮对改变体脂分布有一定的作用，但对血脂无明显作用。
Objective To investigate the effects of dehydroepiandrosterone on body fat distribution and blood lipids in elderly men. Methods Sixty-two elderly obese men with body mass index (BMI) ≥25 were compared between the two groups with different doses of DHEA. Results Oral deshydroepiandrosterone sulfate 25 mg once daily was lower than that before medication (369 ± 052%) after 3 months, and the femoral subcutaneous fat thickness was decreased by 648 ± 221% , Perirenal fat decreased (2 42 ± 1 91)%. Dehydroepiandrosterone sulfate was orally administered 50 mg once daily after 3 months. The BMI decreased (2.36 ± 0.72)% and the thickness of femur subcutaneous fat decreased (1.67 ± 0.89)% after 3 months. Perirenal fat decreased (2 87 ± 1 47%). There was a significant difference between the two groups and the control group (P <005). No significant changes in blood lipids were found. Conclusions Dehydroepiandrosterone in the elderly has a certain effect on the change of body fat distribution, but has no obvious effect on blood lipid.