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在RM—6000八道生理仪上观察了石杉碱甲(又称福定碱)对家兔脑电、肌电、呼吸、血流和血压等八项指标的影响,并测定了它在体内对不同动物胆碱酯酶(ChE)活力的抑制作用。 麻醉家兔iv石杉碱甲0.01mg/kg5min后,部分动物(2/4) 出现一过性脑电低幅快波和偶发的肌电;该剂量对脑和血ChE活力无抑制作用。iv石杉碱甲0.05mg/kg后5～20min内动物出现脑电去同步化反应和自发肌电;延脑、大脑皮层、红细胞和血浆ChE活力分别抑制23.1,17.7,13.2和17.5％。iv石杉碱甲0.25mg/kg后1min出现脑电持续性去同步化反应与高频高幅的肌电,呼吸变浅、变快(后期变慢),血流下降,但血压、
The effects of huperzine A (also known as furadine) on eight indexes including EEG, EMG, respiration, blood flow and blood pressure in rabbits were observed in RM-6000 eight-channel physiology instrument. Inhibition of cholinesterase (ChE) activity in different animals. Anesthetize rabbit huperzine a 0.01mg / kg 5min, some animals (2/4) appeared transient electroencephalogram amplitude wave and occasional EMG; the dose of brain and blood ChE activity was not inhibited. The animals were exposed to Huperzine A 0.05mg / kg for 5 ~ 20min after EEG desynchronization and spontaneous myoelectricity. The activities of brain, brain cortex, erythrocyte and plasma ChE were inhibited by 23.1,17.7,13.2 and 17.5% respectively. I Huperzine A 0.25mg / kg after 1min EEG appeared desynchronization reaction and high frequency high amplitude EMG, breathing shallow, fast (late slow), blood flow decreased, but blood pressure,