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生长迟缓是儿童时期尿毒症的严重合并症，胰岛素样生长因子结合蛋白（ＩＧＦＢＰｓ）在尿毒症中的作用已引起关注。６种ＩＧＦＢＰＳ存在血液和组织液中，它们特异性与胰岛素样生长因子（ＩＧＦｓ）结合，并且调节其输送以及与特异性组织细胞受体结合。同时ＩＧＦＢＰｓ也受生长激素、ＩＧＦｓ、营养以及蛋白酶等调节。在慢性肾功能衰竭（ＣＲＦ）时，大量小分子ＩＧＦＢｐｓ在机体内储积。目前认为ＣＲＦ血浆中ＩＧＦＢＰｓ抑制了ＩＧＦｓ的生物活性，成为ＣＲＦ的生长障碍的原因之一。这种改变可能与肾脏功能障碍及ＩＧＦＢＰｓ清除减少有关，而与营养和生长激素治疗关系较小。
Growth retardation is a serious complication of childhood uremia, and the role of insulin-like growth factor binding proteins (IGFBPs) in uremia has attracted attention. Six IGFBPs are present in the blood and in the tissue fluid, which specifically bind to insulin-like growth factors (IGFs) and regulate their delivery and binding to specific tissue cell receptors. IGFBPs are also regulated by growth hormones, IGFs, nutrition and proteases. In chronic renal failure (CRF), a large number of small molecule IGFBps accumulate in the body. It is currently thought that IGFBPs in plasma of CRF inhibit the biological activity of IGFs and become one of the reasons for the growth retardation of CRF. This change may be related to renal dysfunction and decreased IGFBPs clearance, but less relevant to nutrition and growth hormone therapy.