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目的观察上皮-间叶转化(EMT)的标记分子在胰腺癌组织中的表达情况以及与胰腺癌恶性生物学行为的相关性。方法采用免疫组织化学的方法检测56例胰腺癌组织中Snail、上皮源性标记物E-cadherin、间叶源性标记物Vimentin蛋白的表达,并与临床病理资料作对照分析。结果56例胰腺癌组织中Snail阳性表达率为36%(20/56),26例中观察到E-cadherin表达的降低,同时6例观察到Vimentin表达上调。Snail的表达和淋巴结转移(P＜0．05)、远处转移(P＜0．01)、E-cadherin的表达降低(P＜0．05)、Vimentin的高表达(P＜0．05)都存在着相关性。而E- cadherin表达的降低和Vimentin的高表达都与胰腺癌的转移存在着明显的相关性。结论Snail在胰腺癌组织中存在着重新表达的现象,Snail可能通过调控上皮一间叶转化从而在胰腺癌的侵袭过程中发挥重要作用。
Objective To observe the expression of epithelial-mesenchymal transition (EMT) marker in pancreatic cancer and its correlation with malignant biological behavior of pancreatic cancer. Methods The expression of Snail, E-cadherin, and Vimentin protein in 56 cases of pancreatic cancer was detected by immunohistochemistry. The results were compared with clinicopathological data. Results Snail positive expression rate was 36% (20/56) in 56 cases of pancreatic cancer. The decrease of E-cadherin expression was observed in 26 cases, and up-regulation of Vimentin expression was observed in 6 cases. Snail expression and lymph node metastasis (P<0.05), distant metastasis (P<0.01), E-cadherin expression decreased (P<0.05), Vimentin expression was high (P<0.05) There is a correlation. However, the decrease of E-cadherin expression and the high expression of Vimentin have a significant correlation with the metastasis of pancreatic cancer. Conclusion There is a re-expression of Snail in pancreatic cancer. Snail may play an important role in the invasion of pancreatic cancer by regulating epithelial mesenchymal transition.