人的血浆含有几种蛋白酶抑制剂,这些蛋白酶抑制剂约占血浆总蛋白含量的10%.如广谱抑制剂α_2-巨球蛋白即为重要一例.但这类抑制剂中研究最多、血浆含量最高的是具有特异性的α_1-抗胰蛋白酶,虽然它可以抑制大部分的丝氨酸蛋白酶,但它主要是抑制弹性蛋白酶特别是抑制嗜中性白细胞释放的弹性蛋白酶.现已证明α_1-抗胰蛋白酶是一族新的同源蛋白的主要成员.这一族同源蛋白可以抑制丝氨酸蛋白酶,故统称为丝氨酸蛋白酶抑制剂(serpin).研究α_1-抗胰蛋白酶所获 Human plasma contains several protease inhibitors, and these protease inhibitors account for about 10% of the total plasma protein content. For example, the broad-spectrum inhibitor α_2-macroglobulin is an important example. However, the most studied and plasma content of these inhibitors. The highest is the specific α_1-antitrypsin. Although it can inhibit most of the serine proteases, it is mainly the elastase that inhibits elastase, especially the release of neutrophils. α_1-antitrypsin has been proved. It is a major member of a new family of homologous proteins. This family of homologous proteins can inhibit serine proteases and are collectively referred to as serpins. Research into alpha-1-antitrypsin