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肿瘤的发生和发展是多基因、多因素、多步骤综合作用的结果,其中包括肿瘤抑制基因在肿瘤的发生和发展中起的重要作用,肿瘤抑制基因的研究及其作用机制是当今研究的热点之一。CC3基因是1997年Shtivelman用RNA差异显示技术比较高转移性小细胞肺癌细胞系(v-SCLC)与低转移性小细胞肺癌细胞系(c-SClC)时首先发现的一种与肿瘤转移抑制相关的新基因。它在c-SCIC中高表达,而在v-SCLC中低表达或不表达。到1998年Xi-ao等2 发现了一种分子量为30KD的转录共分子,
The occurrence and development of tumors are the result of multi-gene, multi-factor and multi-step comprehensive effects, including the important role of tumor suppressor genes in the occurrence and development of tumors. The study of tumor suppressor genes and their mechanism of action are the hot topics in the research nowadays one. The CC3 gene was first discovered by Shtivelman in 1997 when compared with metastatic small cell lung cancer cell line (v-SCLC) and low metastatic small cell lung cancer cell line (c-SClC) using RNA differential display technique The new gene. It is highly expressed in c-SCIC but low or not expressed in v-SCLC. By 1998 1998 Xi-ao 2 found a molecular weight of 30KD transcription co-molecule,