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用葡萄球菌肠毒素Ａ刺激体外培养的大鼠脾细胞所获得的γ－干扰素（ＩＦＮ－γ），于接种约氏疟原虫子孢子前５ｈ静注于Ｗｉｓｔａｒ大鼠体内，子孢子接种４２ｈ后肝内红外期（ＥＥＦ）数量显著减少，其子孢子发育率仅为对照组的７％～２０％，但ＥＥＦ的大小及成熟度均未受影响。大鼠接种子孢子后２ｈ给ＩＦＮ－γ，则红外期的密度、子孢子发育率及红外期大小，成熟度均与对照组无明显差异。将子孢子与ＩＦＮ－γ共孵４０ｍｉｎ，然后超速离心洗脱ＩＦＮ－γ后再接种于大鼠，则红外期的密度、大小、成熟度也均类似于对照组。结果提示：ＩＦＮ－γ的抗疟作用并非是针对子孢子或红外期本身，而是通过修饰枯否氏细胞活性，减少入侵肝细胞的子孢子数来表达的。
Γ-Interferon (IFN-γ) obtained from staphylococcal enterotoxin A-stimulated rat splenocytes was intravenously injected into Wistar rats 5h before the inoculation of P. yohii sporozoites, and after 42h of sporulation The number of intrahepatic IR (EEF) was significantly reduced, and its sporozoite development rate was only 7% ~ 20% of the control group, but the size and maturity of EEF were not affected. 2h after inoculation of sporozoites to IFN-γ, the infrared density, sporozoite development rate and infrared size, maturity and the control group no significant difference. The sporozoites were incubated with IFN-γ for 40 min, then IFN-γ was eluted by ultracentrifugation and then inoculated into rats. The density, size and maturity of IR were also similar to that of the control group. The results suggest that the anti-malarial effect of IFN-γ is not directed against the sporozoites or the infra-red phase itself but rather by modifying the activity of Kupffer cells and reducing the number of sporozoites invaded by hepatocytes.