目的考察马钱子碱经皮给药后在小鼠体内的药物动力学过程。方法建立了利用HPLC法测定小鼠血浆中马钱子碱质量浓度的方法,测定了iv 4 mg/kg马钱子碱溶液、经皮给药40 mg/kg马钱子碱后的血药浓度,并对结果进行药动学拟合。结果马钱子碱iv和经皮给药后的药动学均符合二室模型。经皮给药后的绝对生物利用度为32.8%,MRT是iv的8倍。结论经皮给药途径可能有利于马钱子碱的减毒增效。 Objective To investigate the pharmacokinetics of brucine in mice after transdermal administration. Methods The method of determining the concentration of brucine in mouse plasma by HPLC was established. The concentration of brucine in iv 4 mg / kg solution and the transdermal administration of 40 mg / kg brucine were measured. , And the results of pharmacokinetic fitting. Results Both strychnine iv and pharmacokinetics after transdermal administration were consistent with a two-compartment model. The absolute bioavailability after transdermal administration was 32.8% and the MRT was 8 times that of iv. Conclusion Transdermal administration may be beneficial to the attenuation and efficiency of brucine.