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目的观察维生素D3用于小儿佝偻病预防的临床效果。方法选取2011年1月-2013年12月期间在医院出生的佝偻病高危婴幼儿90例。随机分为试验组与对照组各45例。均给予一般性预防指导,同时试验组增加维生素D3口服,比较2组佝偻病发病率与碱性磷酸酶活性值。结果试验组的磷酸酶活性值<200μ/L 43例(95.56%);对照组是27例(60.00)。2组比较,差异有统计学意义(P<0.05)。试验组发病2例,均诊断为轻度佝偻病,发病率是4.44%,无任何研究对象出现任何不良症状;对照组发病18例,其中诊断为轻度佝偻病14例,中度佝偻病4例,发病率是40%,对照组的发病率明显高于试验组,组间比较差异具有统计学意义(P<0.05)。结论对佝偻症高危人群合理预防使用维生素D3,可有效减轻佝偻症严重程度或避免佝偻症发生。
Objective To observe the clinical effect of vitamin D3 in the prevention of pediatric rickets. Methods Ninety high-risk infants with rickets in the hospital from January 2011 to December 2013 were selected. Randomly divided into experimental group and control group of 45 cases. Were given general preventive guidance, while the experimental group increased vitamin D3 oral administration, the incidence of rickets in two groups compared with alkaline phosphatase activity values. Results In the test group, the activity of phosphatase was less than 200μ / L in 43 cases (95.56%) and in the control group was 27 cases (60.00). The difference between the two groups was statistically significant (P <0.05). In the experimental group, 2 cases were diagnosed as mild rickets, the incidence rate was 4.44%, there was no adverse symptoms in any subjects; 18 cases in the control group were diagnosed as mild rickets in 14 cases, moderate rickets in 4 cases, The rate was 40%, the incidence of the control group was significantly higher than the experimental group, the difference between the groups was statistically significant (P <0.05). Conclusion The prevention of vitamin D3 in high risk population of rickets may be effective in reducing the severity of rickets or preventing the occurrence of rickets.