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目的 :关注儿童过敏性紫癜早期肾损伤标志物,探讨黄葵佐治儿童过敏性紫癜早期肾损伤尿白蛋白(ALB)、白蛋白/肌酐(ALB/Cr)、肾损伤分子-1(KIM-1)的变化。方法:选择2015年5月—2016年5月来院就诊的过敏性紫癜早期肾损伤患儿60例,其中30例使用黄葵佐治(黄葵和盐酸贝那普利治疗),另外30例使用盐酸贝那普利治疗,2周后观察其尿ALB、ALB/Cr、KIM-1的变化。选择儿科门诊正常体检的儿童30例作为对照组。结果 :黄葵组与盐酸贝那普利组治疗后尿ALB、ALB/Cr、KIM-1较治疗前显著下降(P<0.01),两组治疗后比较,前者降低尿ALB、ALB/Cr、AKM-1更加明显(P<0.01)。结论:黄葵佐治儿童过敏性紫癜早期肾损伤疗效好,前景广阔。
OBJECTIVE: To investigate the early renal injury markers of childhood Henoch-Schonlein purpura and to explore the relationship between albumin / albumin / creatinine (ALB / Cr) and renal injury molecule-1 (KIM-1) )The change. METHODS: Sixty children with early renal impairment of allergic purpura were enrolled in our hospital from May 2015 to May 2016, of which 30 were treated with the yellow sunflower and benazepril hydrochloride, and the other 30 with hydrochloric acid Benazepril treatment, 2 weeks after the change of urine ALB, ALB / Cr, KIM-1. Thirty children were selected as normal control group. Results: The ALB, ALB / Cr and KIM-1 in the Huangkuai group and benazepril hydrochloride group were significantly lower than those before treatment (P <0.01) AKM-1 was more obvious (P <0.01). Conclusion: Huang Kui treatment of children with Henoch-Schonlein purpura early renal injury with good efficacy and broad prospects.