长链非编码RNA是没有编码蛋白质功能且转录本长度＞200 nt的RNA，通过表观遗传、转录和转录后水平调节基因的表达。近年来，长链非编码RNA作为一个新的生物标志在心血管疾病的发生发展中越来越受到重视，但对其在心脏的发育及多种心血管疾病的调控作用仍未阐明。现从分类、调控机制及在心血管疾病中的研究进展进行综述，为长链非编码RNA的深入研究，临床心血管疾病的预防、治疗提供重要策略和潜在靶点。“,”Long non-coding RNAs(lncRNAs) are≥200 nucleotides in length and do not have protein-coding potential.The available data indicates that lncRNAs are involved in a variety of different mechanisms of gene expression such as epigenetic ,transcription and post-transcription regulation .Recently,lncRNAs as novel biomarks are seen as playing a vital role in cardiovascular progress ,but the development of how it regulates cardiovascular development and disease conditions is not illuminated .Thus this review is a convergence of lncRNAs in cat-egory,the regulation of mechanisms and the advances of lncRNAs in cardiovascular diseases to pave the way for more detailed and compre -hensive studies on molecular mechanisms in prevention and treatment for cardiovascular diseases .