1987年3月19日,在纽约科学院由炎症研究协会主办召开了一个有关疼痛与镇痛药的会议。这次会议清晰地阐明了许多疼痛介质在外周组织和中枢神经系统的双重作用。Vaught评述了神经激肽(neuroki-nins,也称为速激肽,tachykinins)及其受体的分类。现已在哺乳动物中鉴定出3种这类神经肽:P物质(SP),神经激肽A(神经激肽α,K物质)和神经激肽B(神经激肽β,neuromedin K),它们均相互作用于各自的受体亚型:NK On March 19, 1987, a conference on pain and analgesics was held at the New York Academy of Sciences by the Institute for Inflammatory Research. The meeting clearly demonstrated the dual role of many pain mediators in peripheral and central nervous systems. Vaught reviews the classification of neurokinins (also known as tachykinins) and their receptors. Three such neuropeptides have now been identified in mammals: substance P (SP), neurokinin A (neurokinin alpha, substance K), and neuromedin B (neuromedin K) All interact with their respective receptor subtypes: NK