The Yom River is one of the four major sediment sources to the Chao Phraya River in Thailand. Human activities and changes in climate over the past six decades may have affected the discharge and sediment load to some extent. In the current study, the river discharge and sediment characteristics in the mainstream of the Yom River were investigated using the field observation data from 2011 to 2013 and the historical river flow and sediment data from 1954 to 2014 at six hydrological stations operated by the Royal Irrigation Department of Thailand (RID). The non-parametric Mann-Kendall test and double mass curve were used to analyze the sediment dynamics and temporal changes in the discharge of the Yom River. The results revealed that the sediment was mainly transported in suspension, and the bed-to-suspended sediment loads ratio varied between 0 and 0.05. The daily suspended sediment load (SSL) in the upper and middle basins had a strong correlation with the daily discharge and could be repre-sented by power equations with coefficients of determination higher than 0.8. The daily suspended sediment load in the lower basin did not directly depend on the corresponding discharge because of the reduction in river slope and water diversion by irrigation projects. It also appeared that the river dis-charges and sediment loads were mainly influenced by climate variation (floods and droughts). More-over, the average sediment transport of the upper, middle, and lower reaches were 0.57, 0.71, and 0.35 million t/y, respectively. The sediment load in the lower basin decreased more than 50％ as a result of changes in the river gradient (from mountainous to floodplain areas). The results from sediment analysis also indicated that the construction of the Mae Yom Barrage, the longest diversion dam in Thailand, and land-use changes did not significantly affect the sediment load along the Yom River.