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系统性红斑狼疮(SLE)容易发生动脉粥样硬化(atherosclerosis,AS)。炎症反应是SLE合并AS的重要机制,多种免疫细胞共同介导炎症反应过程。其中,树突状细胞(dendritic cells,DCs)在调节固有免疫应答、适应性免疫应答乃至整个免疫系统中扮演着重要的角色。越来越多的证据表明DCs的功能异常是SLE合并AS疾病发展的枢纽。
SLE is prone to atherosclerosis (AS). Inflammatory reaction is an important mechanism of SLE combined with AS, a variety of immune cells co-mediated the inflammatory reaction process. Among them, dendritic cells (DCs) play an important role in regulating innate immune responses, adaptive immune responses and even the entire immune system. There is growing evidence that the dysfunction of DCs is the hub of the development of SLE with AS disease.