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目的探讨血清氨基末端脑钠肽(NT-proBNP)、纤维蛋白原(Fg)、血管性假血友病因子(vWF)、D-二聚体(D-D)和超敏C-反应蛋白(hs-CRP)水平与维持性血液透析患者心血管疾病发病的相关性。方法选取该院就诊的维持性血液透析患者220例,治疗期间发生心血管疾病者60例作为A组,未发生心血管疾病者160例作为B组。同期收集体检健康志愿者100例作为C组。分别检测各组患者和健康志愿者NT-proBNP、Fg、vWF、D-D和hs-CRP水平,分析其差异和相关性。结果经检测A组患者血清NT-proBNP、Fg、vWF、D-D和hs-CRP水平最高,B组次之,C组最低,两两比较差异均有统计学意义(P<0.05)。结论血清NT-proBNP、Fg、vWF、D-D和hs-CRP水平较高的维持性血液透析患者具有较高的心血管疾病发生可能性。
Objective To investigate the effects of serum NT-proBNP, fibrinogen (Fg), vWF, DD and hs- CRP) and the maintenance of hemodialysis patients with cardiovascular disease incidence. METHODS: A total of 220 patients with maintenance hemodialysis were enrolled in this study. Sixty patients with cardiovascular disease during the treatment period were enrolled as group A and 160 patients without cardiovascular disease as group B. In the same period, 100 healthy volunteers were collected as C group. The levels of NT-proBNP, Fg, vWF, D-D and hs-CRP in each group of patients and healthy volunteers were detected and their differences and correlations were analyzed. Results The serum levels of NT-proBNP, Fg, vWF, D-D and hs-CRP in group A were the highest, group B was the second, group C was the lowest, and the difference was statistically significant (P <0.05). Conclusions Maintenance hemodialysis patients with high levels of NT-proBNP, Fg, vWF, D-D and hs-CRP may have a higher incidence of cardiovascular disease.