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第一秒时间肺活量(FEV_(1.0))为0.48～3.00l的10名慢性支气管炎患者,吸入以锝99(~(99m)Tc)标记的聚苯乙烯颗粒。颗粒大小为5μm(±0.8SD)。吸入时潮气容量(V_T)在750～1830ml之间。在吸入后5小时内按一定时间间隔连续作全肺γ-射线计数。所得资料以占吸入后第一次计数的百分比表示。由此画出每人吸入后5小时内全肺对吸入颗粒的清除曲线。人为地以吸入后1.5小时为界分0～1.5小时和1.5～5.0小时两期。第一期中个体之间清除率以—0.0013%/分～—0.0180%/分,明显不同,而在第二期,个体之间较接近,为—0.0008%/分～—0.0036%/分。吸入颗粒后即从胸部中线开始向外侧每隔1小时作右肺纵切扫描计数。每人测5英寸。所得资料以占计数总和之百分比表示。结果发现此百分数与测定部位距中线英寸数之间呈直线回归关系,其斜率(D)为负值。可见吸入颗粒从中线向外侧逐渐减少。可用D表示颗粒在肺中沉积的深度,其绝对值越小,则此回归直线越近于水平,说明吸入之颗粒沉积越深。5小时滞留率(即1～5小时清除率%)与上述回归直线的斜率(D)的绝对值有显著的负相关。(5小时滞留率[%]=69.12—3.02 D,r=—0.76,P<0.05)。由此说明颗粒在人肺中沉积越深则5小时滞留率越高而清除率越低。以逐步回归求得5小时滞留率与V_T和FEV_(1.0)的回归系数皆为正数,且是显著
Ten chronic bronchitis patients with spirometry (FEV_ (1.0)) of 0.48 to 3.00 l in the first second time inhaled polystyrene particles labeled with technetium 99 (~ (99m) Tc). The particle size is 5 μm (± 0.8 SD). Moisture when inhaled capacity (V_T) between 750 ~ 1830ml. Within 5 hours after inhalation, the whole lung γ-ray count was continuously taken at certain time intervals. The information obtained is expressed as a percentage of the first count after inhalation. Thus draw the whole lung within 5 hours after inhalation particles inhalation curve. Artificially 1.5 hours after inhalation for the boundaries of 0 to 1.5 hours and 1.5 to 5.0 hours two. The clearance rate of individuals in the first phase was -0.0013% / min ~ -0.0180% / min, which was significantly different. In the second phase, the clearance rate of individuals was -0.0008% / min ~ -0.0036% / min. After inhalation of particles from the midline of the chest to the outside every 1 hour for longitudinal lung scan count. 5 inches per person. The information obtained is expressed as a percentage of the sum of the counts. The results showed a linear regression between the percentage and the measured midline inches, with a negative slope (D). Visible inhalation particles gradually reduced from the midline to the outside. D can be used to represent the depth of deposition of particles in the lung, the absolute value of the smaller, then the regression line closer to the level, indicating that the inhalation of the deeper particles. The 5-hour retention (ie, 1 to 5 hours clearance%) is significantly negatively correlated with the absolute value of the slope (D) of the regression line. (5-hour retention [%] = 69.12-3.02 D, r = -0.76, P <0.05). This shows that the deeper the deposition of particles in the human lung 5h retention rate is higher and the lower the clearance rate. The regression coefficients of 5-hour retention rate and V_T and FEV_ (1.0) were all positive with stepwise regression, and were significant