帕金森病(PD)早期临床表现不典型,如能早期诊断、积极治疗,有可能减缓病程进展。因此,早期明确诊断、积极治疗是非常必要的。经颅超声成像(TCS)是一种新的非侵入性超声成像技术,发现PD患者的黑质(SN)区回声增强,认为这些回声增强区的性质与SN区的铁含量增高有关(1)。结合近几年国外对TCS检查在PD早期诊断及鉴别诊断中的应用、优点及局限性的研究做一综述。 Parkinson’s disease (PD) atypical early clinical manifestations, such as early diagnosis and aggressive treatment, may slow down the course of the disease. Therefore, early diagnosis, active treatment is very necessary. Transcranial ultrasound imaging (TCS) is a new noninvasive ultrasound imaging technique and found that the echogenicity of the SN region of PD patients was enhanced, suggesting that the properties of these echogenic regions are associated with an increase in iron content in the SN region (1) . In the light of the application, advantages and limitations of TCS examination in early diagnosis and differential diagnosis of PD in foreign countries in recent years, a review is given.