地方性呆小病是一种危害人民健康的多发病。对其病因目前说法不一,有人主张是环境缺碘所致,有人认为和遗传有关。为了探讨地方性呆小病的病因,并为早期诊断提供依据,我们在家系调查的同时进行了皮肤纹理的研究。同西宁正常人的手脚皮纹做了对比分析,并和国内有关的文献进行了比较。现报告如下: Endemic small ailments is a common disease that endangers people’s health. The current etiology is not the same, some people claim that the environment caused by iodine deficiency, some people think and genetic. In order to explore the etiology of endemic asclerosis and to provide a basis for early diagnosis, we investigated the skin texture at the same time as our pedigree. With the normal Xining hand and foot skin pattern made a comparative analysis, and the domestic literature has been compared. The report is as follows: