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为了观察冻干甲型肝炎 腮腺炎联合疫苗免疫恒河猴后的安全性及免疫原性 ,用静脉注射和丘脑注射的方式接种疫苗 ,观察恒河猴的临床症状、体征、生化、免疫学反应以及脑和肝组织的病理变化。结果未见临床症状和体征的异常改变 ,ALT正常 ,抗 HAV、抗流行性腮腺炎病毒的抗体在观察期内持续阳性 ,脑组织和肝组织无病毒性肝炎和腮腺炎病毒引起的病理性改变。因此该冻干甲型肝炎 腮腺炎联合疫苗抗原间无干扰 ,具有良好的安全性及免疫原性。
In order to observe the safety and immunogenicity of the immunized rhesus monkeys with the combination vaccine of freeze-dried hepatitis A and mumps, the vaccination was given by intravenous injection and thalamic injection to observe the clinical symptoms, signs, biochemical and immunological reactions of rhesus monkeys As well as pathological changes of brain and liver tissue. The results showed no abnormal changes of clinical symptoms and signs, normal ALT, anti-HAV, anti-mumps virus antibodies continued to be positive during the observation period, brain and liver tissue without viral hepatitis and mumps virus pathological changes . Therefore, the freeze-dried hepatitis A mumps vaccine antigen without interference, with good safety and immunogenicity.