N-methyl-D-aspartate receptor expression in the spinal dorsal horn of a rat model of formalin-induce

来源 :中国神经再生研究(英文版) | 被引量 : 0次 | 上传用户:mingliqq
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Clinical and animal experiments have proved that intrathecal injection of butorphanol has an analgesic effect. However, whether the analgesic effect is associated with activation of the N-methyl-D-aspartate (NMDA) receptor remains unclear. This study presumed that intrathecal injection of butorphanol has an analgesic effect on formalin-induced inflammatory pain in rats, and its analgesic effect is associated with inhibition of NMDA receptors. Concurrently, ketamine was injected into the intrathecal space, which is a non-competitive NMDA receptor antagonist, to determine the analgesic mechanism of butorphanol. The total reflection time in phase 1 and phase 2 of rat hind paws carding action was reduced when the butorphanol dose was increased to 25 μg,or a low dose of butorphanol was combined with ketamine. Intrathecal injection of a high dose of butorphanol alone or a Iow dose of butorphanol combined with ketamine can remarkably reduce NMDA receptor expression in the L5 spinal dorsal h of formalin-induced pain rats. The results suggest that intrathecal injection of butorphanol has analgesic effects on formalin-induced inflammatory pain, and remarkably reduces NMDA receptor expression in the rat spinal dorsal h.Ketamine strengthens this analgesic effect. The analgesic mechanism of intrathecal injection of butorphanol is associated with inhibition of NMDA receptor activation.
其他文献
Recent studies have demonstrated that ferulic acid[3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid]and sodium ferulate produce protective effects against glutama
Based on the hypothesis that upstream factor inhibition results in better treatment effects than downstream factor inhibition,the present study interfered with
期刊
目的总结利普刀(LEEP刀)治疗宫颈癌前病变的临床疗效。方法 63例宫颈癌前病变患者,均接受LEEP刀治疗,评价其临床治疗效果。结果 63例患者中一次性完全切除59例(93.65%),手术
A bioactive compound from Paecilomyces tenuipes(BCPT)has an inhibitory effect on monoamine oxidase A(MAO-A)in vitro.Researchers have thought that BCPT may be a
Previous studies using magnetic resonance imaging(MRI)and functional MRI to study depression have primarily focused on proton magnetic resonance spectroscopy(1H
目的 探究分析性激素6项在不孕症诊断治疗中的临床应用.方法 选取200例不孕症女性患者设为观察组,同期100例体检健康女性志愿者作为对照组,两组研究对象均进行性激素6项指标
The phosphatidylinositol-3 kinase (PI3K)/Akt pathway and brain-derived neurotrophic factor (BDNF) are involved in neurological functional recovery following cer
In vitro studies have demonstrated that many factors of bone morphogenetic proteins (BMPs) induce cholinergic differentiation of neural stem cells. However, BMP
目的探讨异位妊娠患者采取腹腔镜手术治疗的临床效果。方法选取行腹腔镜手术治疗的46例异位妊娠患者作为观察组,另选取同期接受开腹手术治疗的30例异位妊娠患者作为对照组。