目的:研究基质金属蛋白酶-9(MMP-9)在HELLP综合征患者血清中的表达,探讨其与HELLP综合征发病的关系及相关性。方法:采用酶联免疫吸附试验检测25～28孕周300例孕妇血清MMP-9的表达,并进行定期随访。结果:67例发展为妊娠期高血压疾病,其中6例发展为HELLP综合征;其余233例中25例早产,208例孕足月分娩(正常妊娠组)。发生HELLP综合征6例孕妇血清中MMP-9表达明显低于正常妊娠组,差异有统计学意义(P<0.01)。结论:HELLP综合征孕妇血清MMP-9表达明显低于正常妊娠组,表明MMP-9可能参与HELLP综合征的发生和发展,可谨慎用于HELLP综合征的预测。 Objective: To investigate the expression of matrix metalloproteinase-9 (MMP-9) in the serum of patients with HELLP syndrome and its relationship with the pathogenesis of HELLP syndrome. Methods: Serum MMP-9 levels were detected by enzyme-linked immunosorbent assay in 300 pregnant women between 25 and 28 gestational weeks and followed up regularly. Results: Sixty-seven cases developed Hypertensive disorder during pregnancy, of which 6 developed HELLP syndrome. Of the remaining 233 cases, 25 were premature and 208 were delivered full term (normal pregnancy group). 6 cases of HELLP syndrome serum MMP-9 expression was significantly lower than the normal pregnancy group, the difference was statistically significant (P <0.01). Conclusion: The serum level of MMP-9 in pregnant women with HELLP syndrome is significantly lower than that in normal pregnant women, indicating that MMP-9 may be involved in the occurrence and development of HELLP syndrome. It may be cautious in the prediction of HELLP syndrome.