本文考察了某些渗透促进剂如月桂氮酮（ＡＺ）、油酸（ＯＡ）、泊洛沙姆（ＰＯＬ）和丙二醇（ＰＧ）等对胰岛素体外经皮离子导入渗透性的影响。结果表明ＡＺ对离子导入具有协同作用，ＰＧ能够增强这种作用，三者并用对胰岛素的经皮渗透具有特别显著的促渗效果。５％ＡＺ／ＰＧ与离子导入并用后，较单独离子导入处理组的促渗因子为２．７５。ＯＡ不能增强离子导入的作用。离子导入与某些渗透促进剂并用为胰岛素等大分子多肽类药物的透皮给药提供了新的思路和可能。 This article examines the effect of certain permeation enhancers such as Azone (AZ), oleic acid (OA), poloxamer (POL) and propylene glycol (PG) on percutaneous iontophoretic penetration of insulin. The results show that AZ has a synergistic effect on iontophoresis. PG can enhance this effect, and the combination of the three has a particularly remarkable effect of promoting transdermal penetration of insulin. When 5% AZ / PG was used together with iontophoresis, the enhancement factor of the single iontophoresis group was 2.75. OA does not enhance the effect of iontophoresis. Ion introduction with some permeation enhancers and the use of insulin and other macromolecular peptides through transdermal delivery of new ideas and possibilities.