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为探讨一氧化氮（ＮＯ）在听源性惊厥点燃中的可能作用，用ＮＡＤＰＨ－黄递酶组织化学方法和Ｆｏｓ免疫细胞化学方法，研究了听源性惊厥易感大鼠惊厥和点燃后听觉核团和前脑结构内ＮＯＳ－Ｆｏｓ双重阳性神经元的分布及差异。结果显示：一次惊厥后，下丘内双重阳性神经元较多，近７０％～８０％的ＮＯＳ阳性神经元呈Ｆｏｓ阳性，其他听觉核团和前脑结构内仅见少量ＮＯＳ－Ｆｏｓ双重阳性神经元。点燃后，听觉核团和前脑结构内ＮＯＳ－Ｆｏｓ双重阳性神经元明显增加，而且嗅周皮质第Ⅱ层浅部多数ＮＯＳ弱阳性神经元呈Ｆｏｓ阳性，第Ⅲ层出现大量ＮＯＳ－Ｆｏｓ双重阳性神经元。上述结果表明，听源性惊厥点燃诱导ＮＯＳ表达增加，ＮＯ可能参与提高神经元的易感性
To investigate the possible role of nitric oxide (NO) in the auditory convulsion of the convulsions, NADPH-diaphorase histochemistry and Fos immunocytochemistry were used to investigate the effects of convulsions and post-ignition auditory convulsions Distribution and Difference of NOS-Fos Double Positive Neurons in Nucleus and Forebrain Structure. The results showed that there were more double positive neurons in the inferior colliculus after one convulsion. Fos was positive in nearly 70% -80% of NOS positive neurons, and only a few NOS-Fos double positive neurons in other auditory nuclei and forebrain structures . After ignition, NOS-Fos double positive neurons in the auditory nucleus and forebrain structures increased significantly, and most of the NOS weak positive neurons in the superficial layers of olfactory week cortex were Fos positive, and a large number of NOS-Fos double positive Neurons. These results suggest that auditory convulsion-induced increase in NOS expression and NO may be involved in neuronal predisposition