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目的:探索六味地黄方对Barrett食管进展为食管腺癌的预防作用。方法:40只SD大鼠行食管空肠吻合术建立Barrett食管诱发腺癌动物模型,随机分为六味地黄方组和对照组,分别予六味地黄颗粒溶液、生理盐水灌胃,并加用右旋糖酐铁促癌模拟癌变病程,28周后统一处死,镜下观察食管异型增生、Barrett食管、腺癌的发病率。结果:两组均可见严重食管炎、异型增生、Barrett食管和腺癌,六味地黄颗粒组腺癌发生率为9.09%(1/11),明显低于对照组的36.36%(4/11),但差异并无统计学意义(P>0.05)。结论:六味地黄方有降低Barrett食管癌变的趋势,可能对阻断Barrett食管进展为腺癌有一定的作用,有待进一步研究。
Objective: To explore the preventive effect of Liuwei Dihuang Recipe on esophageal adenocarcinoma of Barrett’s esophagus. Methods: Forty SD rats were treated with esophagogastric jejunostomy to establish an animal model of Barrett esophagus-induced adenocarcinoma. They were randomly divided into Liuweidihuang group and control group. The rats were given Liuweidihuang granule solution and normal saline respectively. Cancer simulate the course of cancer, after 28 weeks unified death, microscopic observation esophageal dysplasia, Barrett’s esophagus, the incidence of adenocarcinoma. Results: Severe esophagitis, dysplasia, Barrett ’s esophagus and adenocarcinoma were found in both groups. The incidence of adenocarcinoma was 9.09% (1/11) in Liuweidihuang granule group, significantly lower than that in control group (36.36%, 4/11) But the difference was not statistically significant (P> 0.05). Conclusion: Liuweidihuang Decoction can reduce the tendency of Barrett ’s esophageal cancer and may play a certain role in blocking the progression of Barrett’ s esophagus as adenocarcinoma. It needs further study.