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目的:观察早产儿呼吸窘迫综合征使用肺表面活性物质后即刻拔管及继续呼吸机通气2 h再拔管的疗效。方法:将64例早期早产儿分为两组;治疗组32例使用肺表面活性物质(PS)后接常频呼吸机继续机械通气2 h拔管再予连续气道正压通气(CPAP)辅助通气;对照组32例在使用PS后即刻拔管给予CPAP辅助通气;结果:治疗组仅3例需再次气管插管呼吸机辅助通气,发生率9.38%;对照组有12例需再次气管插管继续呼吸机辅助通气,发生率37.50%,差异具有统计学意义(P<0.01)。结论:早期早产儿使用PS后继续接呼吸机机械通气2 h再拔管给予CPAP辅助通气,可以有效的减少再次气管插呼吸机辅助通气,减少有创操作及侵入性感染的几率,提高早产儿的存活率,安全性好。
OBJECTIVE: To observe the effect of extubation immediately after extubation of pulmonary surfactant in patients with respiratory distress syndrome and continue ventilator ventilation for 2 h before premature infants. Methods: Sixty-four cases of early preterm infants were divided into two groups. In the treatment group, 32 cases were treated with pulmonary surfactant (PS) followed by normal-frequency ventilator and mechanical ventilation for 2 h followed by continuous positive airway pressure (CPAP) Ventilation; the control group of 32 patients extubated immediately after the use of PSAP assisted ventilation; Results: The treatment group, only 3 cases required re-tracheal intubation ventilator-assisted ventilation, the incidence of 9.38%; 12 patients in the control group to be tracheal intubation Continued ventilator-assisted ventilation, the occurrence rate of 37.50%, the difference was statistically significant (P <0.01). CONCLUSIONS: Early premature infants with PS can be ventilated for 2 h followed by ventilator extubation for CPAP assisted ventilation, which can effectively reduce the chance of invasive operation and invasive infection and improve premature infants Survival rate, good safety.