纤维粘连蛋白是一种多功能的糖蛋白 ,在细胞外基质中广泛分布。体内仅有单一的FN基因 ,可在ED A、ED B和ⅢCS三个位点上发生可变剪接 ,形成不同的成熟mRNA ,产生多种形式的多肽。纤维粘连蛋白对口腔肿瘤细胞的形态变化、粘附、迁移、增殖和分化 ,以及免疫细胞的功能均有一定作用。对纤维粘连蛋白及其mRNA可变剪切片断的结构、表达、功能、调节的深入研究 ,将为口腔肿瘤的预防、诊断和治疗提供一定的理论依据。 Fibronectin is a versatile glycoprotein that is widely distributed in the extracellular matrix. In vivo, there is only a single FN gene that can undergo alternative splicing at three sites of ED A, ED B and IIICS to form different mature mRNAs and produce various forms of polypeptides. Fibronectin plays a role in the morphological changes, adhesion, migration, proliferation and differentiation of oral tumor cells and the function of immune cells. The further study on the structure, expression, function and regulation of fibronectin and its mutable fragments will provide some theoretical evidences for the prevention, diagnosis and treatment of oral tumors.