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为阐明强心扩血管药羟苯氨酮对心肌与血管的直接影响，采用离体心脏，离体心肌与血管制备，以心肌张力、心率、冠脉流量及血管平滑肌张力为观察指标。结果显示：给离体大鼠心脏灌流羟苯氨酮０１～１μｍｏｌ·Ｌ－１可使心肌收缩力和冠脉流量明显增加，心率轻度减慢。羟苯氨酮剂量依赖性地增加豚鼠乳头肌和左房肌张力，并减慢右房频率。羟苯氨酮（１～５０μｍｏｌ·Ｌ－１）非竞争性地对抗ＫＣｌ，５ＨＴ和ＣａＣｌ２致狗冠状动脉，基底动脉和肠系膜动脉的收缩，显示它有松弛血管平滑肌的作用。与磷酸二酯酶抑制剂类药物米力农作比较，两者的正性肌力作用与扩血管作用相似。然而，羟苯氨酮减慢心搏频率，米力农则增加心率。提示羟苯氨酮有直接正性肌力、负性频率与扩血管作用。
In order to elucidate the direct influence of Cardiac vasodilator on myocardium and blood vessels, cardiac and heart rate, coronary flow and vascular smooth muscle tension were used as indexes in isolated heart, isolated myocardium and blood vessels. The results showed that the myocardial contractility and coronary flow significantly increased after cardiopulmonary administration of oxyphenamone 01 ~ 1μmol·L-1, and the heart rate slowed down slightly. Oxycodone dose-dependently increased guinea pig papillary and left atrial muscle tone, and slowed the right atrial frequency. Oxycodone (1 ~ 50μmol·L-1) against non-competitive KCl, 5HT and CaCl2 caused coronary artery, basilar artery and mesenteric artery contraction, showing that it has the role of relaxation of vascular smooth muscle. Compared with the millet crop, which is a phosphodiesterase inhibitor, the positive inotropic effect was similar to that of vasodilator. However, oxycodone slowed the heart rate, while milrinone increased heart rate. Tip oxycodone direct positive muscle, negative frequency and vasodilator effect.